Thermo Fisher Scientific RAB5 Polyclonal Antibody
RAB5 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합하며, 고순도 Protein A 정제 및 고안정성 저장용액을 제공합니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific RAB5 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human RAB5 (amino acids 8–100) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
RAB5 belongs to the small GTPase Rab family, key regulators of intracellular membrane trafficking—from vesicle formation to membrane fusion. Rabs cycle between inactive GDP-bound and active GTP-bound forms, recruiting downstream effectors that control vesicle formation, movement, tethering, and fusion.
RAB5A is essential for plasma membrane and early endosome fusion, contributes to filopodia extension, and is required for exosomal release of SDCBP, CD63, PDCD6IP, and syndecan. It also regulates maturation of apoptotic cell-containing phagosomes, likely downstream of DYN2 and PIK3C3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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