Thermo Fisher Scientific CD19 Monoclonal Antibody (2E2B6B10)
Human CD19 단백질을 표적으로 하는 Mouse IgG2a 단클론 항체로, WB, IHC, ICC/IF, ELISA에 사용 가능. 비결합형 액상 형태이며, 단기 4°C 보관 및 장기 -20°C 보관 권장. 인간 시료에 높은 반응성을 보여 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2E2B6B10 |
| Immunogen | Purified recombinant fragment of human CD19 expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C and avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10982936 |
Product Specific Information
MA5-15741 targets CD19 in indirect ELISA, IHC, and WB applications and shows reactivity with human samples.
The immunogen used is a purified recombinant fragment of human CD19 expressed in E. coli.
Target Information
CD19 is a member of the immunoglobulin superfamily with two Ig-like domains. It is expressed on nearly all peripheral B cells and appears on certain myeloid leukemia cells, especially monocytic lineage. CD19 acts as a key regulator of normal and malignant B cell proliferation and is expressed in all B cell precursor leukemias.
As a cell surface molecule, CD19 associates with the B cell receptor (BCR) complex to lower the threshold for antigen receptor-dependent stimulation. It functions as a signal-amplifying coreceptor and can also signal independently of BCR co-ligation. Mutations in CD19 can lead to hypogammaglobulinemia, while overexpression can cause B cell hyperactivity.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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