Thermo Fisher Scientific CD122 Polyclonal Antibody
CD122(IL-2 receptor beta)에 특이적인 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC/IF에 사용 가능. Human 시료에 반응하며 항원 친화 크로마토그래피로 정제됨. 4°C 단기 보관, -20°C 장기 보관 권장. 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region within amino acids 487–551 of Human IL2 Receptor beta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546311 |
Product Specific Information
- Recommended positive control: Raji
- Predicted reactivity: Chimpanzee (100%)
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
CD122 (Interleukin 2 receptor) is involved in T cell-mediated immune responses, primarily expressed in the hematopoietic system and exists in three forms:
- Low affinity form: Alpha subunit monomer, not involved in signal transduction
- Intermediate affinity form: Alpha/beta subunit heterodimer
- High affinity form: Alpha/beta/gamma subunit heterotrimer
Both intermediate and high affinity forms participate in receptor-mediated endocytosis and mitogenic signal transduction.
The CD122 gene encodes the beta subunit, a type I membrane protein.
Dysfunction of CD122 is associated with diseases such as oligoarticular juvenile idiopathic arthritis and rheumatoid factor negative juvenile idiopathic arthritis.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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