Thermo Fisher Scientific UMOD Polyclonal Antibody, MaxPab

Applications

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MGQPSLTWML MVVVASWFIT TAATDTSEAR WCSECHSNAT CTEDEAVTTC TCQEGFTGDG LTCVDLDECA IPGAHNCSAN SSCVNTPGSF SCVCPEGFRL SPGLGCTDVD ECAEPGLSHC HALATCVNVV GSYLCVCPAG YRGDGWHCEC SPGSCGPGLD CVPEGDALVC ADPCQAHRTL DEYWRSTEYG EGYACDTDLR GWYRPHPSSD EGIVSRKACA HWSGHCCLWD ASVQVKACAG GYYVYNLTAP PECHLAYCTD PSSVEGTCEE CSIDEDCKSN NGRWHCQCKQ DFNITDISLL EHRLECGAND MKVSLGKCQL KSLGFDKVFM YLSDSRCSGF NDRDNRDWVS VVTPARDGPC GTVLTRNETH ATYSNTLYLA DEIIIRDLNI KINFACSYPL DMKVSLKTAL QPMVSALNIR VGGTGMFTVR MALFQTPSYT QPYQGSSVTL STEAFLYVGT MLDGGDLSRF ALLMTNCYAT PSSNATDPLK YFIIQDRCPH TRDSTIQVVE NGESSQGRFS VQMFRFAGNY DLVYLHCEVY LCDTMNEKCK PTCSGTRFRS GSVIDQSRVL NLGPITRKGV QATVSRAFSS LGLLKVWLPL LLSATLTLTF Q

Target Information

This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinositol-anchored counterpart on the luminal cell surface of the loop of Henle.
Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids and may provide defense against urinary tract infections caused by uropathogenic bacteria.
Defects in this gene are associated with autosomal dominant renal disorders such as medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN), characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure.
Several transcript variants may exist; two major full-length variants encode the same isoform.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.