Thermo Fisher Scientific UMOD Polyclonal Antibody, MaxPab
UMOD 단백질을 표적으로 하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot, IHC, ICC/IF 등 다양한 응용에 적합합니다. 인간 반응성, 액상 형태, 친화 크로마토그래피 정제, PBS(pH 7.4) 완충액 보관.
- 카탈로그번호
- H00007369-B01P
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | UMOD (AAH35975, 1 a.a. ~ 611 a.a) full-length human protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MGQPSLTWML MVVVASWFIT TAATDTSEAR WCSECHSNAT CTEDEAVTTC TCQEGFTGDG LTCVDLDECA IPGAHNCSAN SSCVNTPGSF SCVCPEGFRL SPGLGCTDVD ECAEPGLSHC HALATCVNVV GSYLCVCPAG YRGDGWHCEC SPGSCGPGLD CVPEGDALVC ADPCQAHRTL DEYWRSTEYG EGYACDTDLR GWYRPHPSSD EGIVSRKACA HWSGHCCLWD ASVQVKACAG GYYVYNLTAP PECHLAYCTD PSSVEGTCEE CSIDEDCKSN NGRWHCQCKQ DFNITDISLL EHRLECGAND MKVSLGKCQL KSLGFDKVFM YLSDSRCSGF NDRDNRDWVS VVTPARDGPC GTVLTRNETH ATYSNTLYLA DEIIIRDLNI KINFACSYPL DMKVSLKTAL QPMVSALNIR VGGTGMFTVR MALFQTPSYT QPYQGSSVTL STEAFLYVGT MLDGGDLSRF ALLMTNCYAT PSSNATDPLK YFIIQDRCPH TRDSTIQVVE NGESSQGRFS VQMFRFAGNY DLVYLHCEVY LCDTMNEKCK PTCSGTRFRS GSVIDQSRVL NLGPITRKGV QATVSRAFSS LGLLKVWLPL LLSATLTLTF Q
Target Information
This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinositol-anchored counterpart on the luminal cell surface of the loop of Henle.
Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids and may provide defense against urinary tract infections caused by uropathogenic bacteria.
Defects in this gene are associated with autosomal dominant renal disorders such as medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN), characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure.
Several transcript variants may exist; two major full-length variants encode the same isoform.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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