Thermo Fisher Scientific Kaiso Polyclonal Antibody
Kaiso 단백질(ZBTB33)을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. Western Blot에 적합하며, 고순도 Affinity Chromatography로 정제되었습니다. PBS/glycerol buffer에 보존되며 연구용으로 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ZBTB33 (Accession Q86T24), corresponding to amino acid residues Q106–A156 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852388 |
Product Specific Information
Antibody detects endogenous levels of total ZBTB33.
Target Information
This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, binding both methylated CGCG and the non-methylated consensus KAISO-binding site TCCTGCNA.
The protein contains an N-terminal POZ/BTB domain and three C-terminal zinc finger motifs.
It recruits the N-CoR repressor complex to promote histone deacetylation and formation of repressive chromatin structures in target gene promoters.
Kaiso may repress Wnt pathway target genes or activate transcription of certain genes via catenin delta-2 (CTNND2) recruitment.
Interaction with catenin delta-1 (CTNND1) inhibits DNA binding.
It also interacts with Importin-alpha 2 (karyopherin alpha2), mediating nuclear import.
Alternatively spliced transcript variants encoding the same protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-103017_Kaiso_Q86T24-1_Rabbit.svg, PA5-103017_Kaiso_Q86T24-1_Rabbit_PDP.jpeg)
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