Thermo Fisher Scientific uPAR (CD87) Polyclonal Antibody
Human uPAR(CD87)을 인식하는 염소 유래 폴리클로날 항체로, Western blot에 적합합니다. 모든 보고된 isoform을 인식하며, 고순도 정제 및 안정적 액상 형태로 제공됩니다. 세포막 단백질 연구 및 암 관련 연구에 유용합니다.
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Applications
Tested Application
- Western Blot (WB): 1–3 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-RTGLKITSLTE |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933867 |
Product Specific Information
- This antibody is expected to recognize all reported isoforms (NP_002650.1; NP_001005376.1; NP_001005377.1).
- Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
The urokinase-type plasminogen activator receptor (uPAR) is a key molecule in regulating cell-surface plasminogen activation and plays an important role in both normal and pathological processes.
Human PLAUR cDNA encodes 335 amino acids, including a predicted signal peptide of 22 residues and a hydrophobic C-terminal portion. The resulting protein (~50 kDa) is highly glycosylated in monocytes and anchored to the plasma membrane via a glycosyl-phosphatidylinositol linkage.
PLAUR (uPAR) associates with the carbohydrate-binding domain of SELL in neutrophil membranes, similar to its interaction with β2 integrins. PLAUR-mediated calcium mobilization is SELL dependent.
uPAR mRNA levels correlate with the invasive potential of endometrial carcinomas, showing a 33-fold increase in advanced-stage tumors compared with normal tissue. uPAR protein expression correlates positively with recurrence rate and mortality in endometrial cancer, making uPAR a useful prognostic marker for advanced disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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