Thermo Fisher Scientific uPAR (CD87) Polyclonal Antibody

Applications

Tested Application

• Western Blot (WB): 1–3 µg/mL

Product Specifications

Product Specific Information

• This antibody is expected to recognize all reported isoforms (NP_002650.1; NP_001005376.1; NP_001005377.1).
• Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.

Target Information

The urokinase-type plasminogen activator receptor (uPAR) is a key molecule in regulating cell-surface plasminogen activation and plays an important role in both normal and pathological processes.
Human PLAUR cDNA encodes 335 amino acids, including a predicted signal peptide of 22 residues and a hydrophobic C-terminal portion. The resulting protein (~50 kDa) is highly glycosylated in monocytes and anchored to the plasma membrane via a glycosyl-phosphatidylinositol linkage.

PLAUR (uPAR) associates with the carbohydrate-binding domain of SELL in neutrophil membranes, similar to its interaction with β2 integrins. PLAUR-mediated calcium mobilization is SELL dependent.

uPAR mRNA levels correlate with the invasive potential of endometrial carcinomas, showing a 33-fold increase in advanced-stage tumors compared with normal tissue. uPAR protein expression correlates positively with recurrence rate and mortality in endometrial cancer, making uPAR a useful prognostic marker for advanced disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.