Thermo Fisher Scientific CD41a Monoclonal Antibody (eBioMWReg30 (MWReg30)), PE-Cyanine7, eBioscience
Mouse CD41a 단백질을 인식하는 Rat IgG1 단클론 항체로, PE-Cyanine7 형광체가 결합되어 있습니다. Flow Cytometry에 최적화되어 있으며, 혈소판 및 조혈 전구세포 분석에 활용 가능합니다. 4°C 보관, 광민감성 주의.
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Thermo Fisher Scientific CD41a Monoclonal Antibody (eBioMWReg30 (MWReg30)), PE-Cyanine7, eBioscience
Applications
- Flow Cytometry (Flow): Tested at 0.5 µg/test
- View 49 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rat / IgG1, kappa |
| Recommended Isotype Control | Rat IgG1 kappa Isotype Control (eBRG1), PE-Cyanine7, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBioMWReg30 (MWReg30) |
| Conjugate | PE-Cyanine7 |
| Excitation / Emission Max | 569 / 780 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1234972 |
Available Formats
- Unconjugated
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Biotin
- eFluor 450
- FITC
- Functional Grade
- NovaFluor Blue 510
- NovaFluor Blue 555
- NovaFluor Blue 660-120S
- NovaFluor Yellow 570
- NovaFluor Yellow 660
- PE
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 645
- Request custom conjugation
Product Specific Information
The eBioMWReg30 monoclonal antibody reacts with mouse CD41 (fibrinogen receptor, gpIIb, integrin alpha IIb).
CD41 is expressed on platelets, megakaryocytes, and hematopoietic progenitors. It associates with CD61 (gpIIIa, integrin beta III) to form a receptor involved in platelet adhesion and aggregation.
Applications Reported: Flow cytometric analysis
Applications Tested: Tested by flow cytometric analysis of mouse platelets (≤ 0.5 µg/test, 100 µL final volume). Cell number should be determined empirically (10⁵–10⁸ cells/test).
Careful titration recommended for optimal performance.
Light Sensitivity: Tandem dye is sensitive to photo-induced oxidation. Protect vial and samples from light.
Fixation: Samples can be stored in IC Fixation Buffer (Product #00-8222) or 1-step Fix/Lyse Solution (Product #00-5333) for up to 3 days at 4°C in the dark.
Excitation: 488–561 nm
Emission: 775 nm
Laser: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
CD41 (platelet glycoprotein IIb, ITGA2B) consists of two subunits (120 kDa alpha and 23 kDa beta) that interact with CD61 in the presence of calcium to form a functional adhesive receptor.
It mediates platelet aggregation and binds to multiple proteins including von Willebrand factor, fibrinogen, fibronectin, and vitronectin.
CD41 is mainly expressed in the megakaryocyte-platelet lineage and during early hematopoietic differentiation.
Associated diseases include Glansmann Thrombasthenia and Platelet type-16 bleeding disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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