Thermo Fisher Scientific RARS Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Immunogen sequence:
VVLGEDKKKF KTRSGETVRL MDLLGEGLKR SMDKLKEKER DKVLTAEELN AAQTSVAYGC IKYADLSHNR LNDYIFSFDK MLDDRGNTAA YLLYAFTRIR SIARLANIDE EMLQKAARET KILLDHEKEW KLGRCILRFP EI

Highest antigen sequence identity to the following orthologs:

• Mouse: 96%
• Rat: 95%

Target Information

The fidelity of protein synthesis requires efficient discrimination of amino acid substrates by aminoacyl-tRNA synthetases. ArgRS (Arginyl-tRNA synthetase), also known as RARS or DALRD1, belongs to the class-I aminoacyl-tRNA synthetase family that includes the related proteins LeuRS, ValRS, and IleRS. These proteins are large monomeric enzymes that catalyze the aminoacylation of tRNA by their cognate amino acid.

ArgRS localizes to the cytoplasm and functions as a monomer but can associate with other tRNA synthetases and auxiliary proteins to form a multisubunit complex. In the presence of ATP, arginine (Arg), and tRNA, ArgRS joins Arg to tRNA(Arg) at its synthetic active site. Two cytoplasmic forms of ArgRS have been described in mammals, differing by the addition of a 73-amino-acid sequence required for ArgRS assembly into the multisubunit complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.