Thermo Fisher Scientific RARS Polyclonal Antibody
Human RARS 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human RARS. Recombinant protein control fragment (Product # RP-102262) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2646319 |
Product Specific Information
Immunogen sequence:
VVLGEDKKKF KTRSGETVRL MDLLGEGLKR SMDKLKEKER DKVLTAEELN AAQTSVAYGC IKYADLSHNR LNDYIFSFDK MLDDRGNTAA YLLYAFTRIR SIARLANIDE EMLQKAARET KILLDHEKEW KLGRCILRFP EI
Highest antigen sequence identity to the following orthologs:
- Mouse: 96%
- Rat: 95%
Target Information
The fidelity of protein synthesis requires efficient discrimination of amino acid substrates by aminoacyl-tRNA synthetases. ArgRS (Arginyl-tRNA synthetase), also known as RARS or DALRD1, belongs to the class-I aminoacyl-tRNA synthetase family that includes the related proteins LeuRS, ValRS, and IleRS. These proteins are large monomeric enzymes that catalyze the aminoacylation of tRNA by their cognate amino acid.
ArgRS localizes to the cytoplasm and functions as a monomer but can associate with other tRNA synthetases and auxiliary proteins to form a multisubunit complex. In the presence of ATP, arginine (Arg), and tRNA, ArgRS joins Arg to tRNA(Arg) at its synthetic active site. Two cytoplasmic forms of ArgRS have been described in mammals, differing by the addition of a 73-amino-acid sequence required for ArgRS assembly into the multisubunit complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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