Thermo Fisher Scientific SNCAIP Polyclonal Antibody, MaxPab

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SNCAIP (AAH94759.1, 1 a.a. approximately 603 a.a) full-length human protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Synphilin 1,uniProtId:Q9Y6H5-1,ncbiNodeId:9606,antigenRange:1-919,antigenLength:919,antigenImageFileName:H00009627-D01P_Synphilin_1_Q9Y6H5-1_Rabbit.svg,antigenImageFileNamePDP:H00009627-D01P_Synphilin_1_Q9Y6H5-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MTYLIQSHHS RRSQNCAEDV IRKTKTDQNG QLECVRWMVS ETEAIAELSC SKDFPSLIHY AGCYGQEKIL LWLLQFMQEQ GISLDEVDQD GNSAVHVASQ HGYLGCIQTL VEYGANVTMQ NHAGEKPSQS AERQGHTLCS RYLVVVETCM SLASQVVKLT KQLKEQTVER VTLQNQLQQF LEAQKSEGKS LPSSPSSPSS PASRKSQWKS PDADDDSVAK SKPGVQEGIQ VLGSLSASSR ARPKAKDEDS DKILRQLLGK EISENVCTQE KLSLEFQDAQ ASSRNSKKIP LEKRELKLAR LRQLMQRSLS ESDTDSNNSE DPKTTPVRKA DRPRPQPIVE SVESMGSAES LHLMIKKHTL ASGGRRFPFS IKASKSLDGH SPSPTSESSE PDLESQYPGS GSIPPNQPSG DPQQPSPDST AAQKVATSPK SALKSPSSKR RTSQNLKLRV TFEEPVVQME QPSLELNGEK DKDKGRTLQR TSTSNESGDQ LKRPFGAFRS IMETLSGNQN NNNNYQAANQ LKTSTLPLTS LGRKTDAKGN PASSASKGKN KAEMYSSCIN LSSNMLIEEH LCNDTRHNDI NRKMKKSYSI KHIAEPESKE LFL

Target Information

Parkinson is the second most common neurodegenerative disease after Alzheimer`s. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. Synuclein alpha interacting protein (Synphilin-1) contains several protein-protein interaction domains and interacts with alpha synuclein in neurons. Mutations of SNCAIP have been linked to Parkinson disease. The amino acid sequence of synphilin-1 shows extensive homology with its human counterpart, especially in regions containing ankyrin-like motifs and the coiled-coil domain. Expression of mouse synphilin-1 in tissues is similar to its human counterpart. Synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1. Role of synphilin-1 in synaptic function and protein degradation and in the molecular mechanisms leading to neurodegeneration in Parkinson disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.