Thermo Fisher Scientific HRH4 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive controls: Jurkat, Raji, NCI-H929, 293T, A431, HeLa, HepG2
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

The Histamine H4 receptor has been reported in human peripheral blood leukocytes, bone marrow, colon, liver, lung, small intestine, spleen, testis, thymus, tonsil, and trachea.
Unlike the mouse H4 receptor, the human gene was not detected in the brain.

G-protein Coupled Receptors (GPCRs) represent one of the largest families of signaling molecules, sharing a structural motif of seven membrane-spanning helices and existing in both active and inactive forms.
Ligand binding induces conformational changes leading to G-protein signaling and downstream effects.
Negative regulation of GPCRs plays a critical role in cellular physiology and continues to drive drug discovery, with notable GPCR-targeted drugs including Zyprexa (Eli Lilly) and Claritin (Schering-Plough).

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.