Thermo Fisher Scientific PPP2R1B Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:

NALQGEVKPV LQKLGQDEDM DVKYFAQEAI SVVAQRLRKL EFPVKDSGEP 
SVPRADKNHF PRPTVPGEDM GKGPVYQLRG DTRDTLAQLG IAELVHFSQS TD

• Highest antigen sequence identity to the following orthologs:
  • Mouse: 79%
  • Rat: 32%

Target Information

In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis, and apoptosis. A group of proteins intimately involved in this process are the protein phosphatases.

The protein phosphatase (PP) holoenzyme is generally a trimeric complex composed of a regulatory subunit, a variable subunit, and a catalytic subunit. Four major families of protein phosphatase catalytic subunits have been identified: PP1, PP2A, PP2B (calcineurin), and PP2C. An additional subunit, PPX (also known as PP4), is a putative member of a novel PP family.

The PP2A family comprises subfamily members PP2A alpha and PP2A beta. The PP2A catalytic subunit associates with a variety of regulatory subunits, including PP2A-A alpha and -A beta, PP2A-B alpha and -B beta, PP2A-C alpha and -C beta, and PP2A-B56 alpha and -B56 beta.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.