Thermo Fisher Scientific ERK5 Polyclonal Antibody
ERK5 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IP에 사용 가능. Human, Mouse 등 다양한 종에 반응하며 Erk1/2와 교차 반응 없음. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성 제공.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
- Publications: View 1 publication
Immunoprecipitation (IP)
- Tested Dilution: 1:50
- Publications: View publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to human Erk5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 23 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10981943 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with Erk1 or Erk2.
Target Information
MAPK7 (ERK5) serine/threonine kinase is a member of the MAP kinase family and is involved in various cellular processes such as proliferation, differentiation, transcription regulation, and development.
MAPK7 is activated by mitogen-activated protein kinase 5 (MAP2K5/MEK5) and participates in downstream signaling of multiple receptors. Upon extracellular stimulation, MAPK7 translocates to the nucleus to regulate gene expression by phosphorylating transcription factors.
Gene deletion of MAPK7 in mice leads to defective blood vessel and cardiac development resulting in embryonic lethality. MAPK7 is essential for endothelial function and vascular integrity.
Four alternatively spliced transcript variants encoding two distinct isoforms have been reported. ERK5 is expressed in many adult tissues—abundantly in heart, placenta, lung, kidney, and skeletal muscle—but not detectable in liver.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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