Thermo Fisher Scientific MAP4K3 Polyclonal Antibody
MAP4K3 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot과 IHC(파라핀) 실험에 적합합니다. 인간 및 생쥐 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:25–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein corresponding to a region derived from internal residues of human Mitogen-activated protein kinase kinase kinase kinase 3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2635728 |
Product Specific Information
This antibody detects endogenous levels of total MAP4K3 protein.
Target Information
MAP4K3 (also known as GLK) is a member of the STE20 family of serine/threonine protein kinases. It contains an N-terminal catalytic domain and a C-terminal regulatory domain. MAP4K3 functions upstream of MEKK1 and is activated by UV radiation and TNF-alpha, leading to activation of the JNK signaling pathway. It can directly activate PKC-T during TCR signaling. Elevated MAP4K3 expression and PKC-T activation have been observed in T cells from individuals with systemic lupus erythematosus. MAP4K3 can act as a pro-apoptotic kinase by promoting activation of BAX through posttranscriptional modulation of PUMA, BAD, and BIM. The kinase activity can be stimulated by UV radiation and TNF-alpha, specifically activating the c-Jun N-terminal kinase (JNK) signaling pathway. It functions upstream of MEKK1 and was formerly known as RAB8-interacting protein-like 1 (RAB8IPL1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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