Thermo Fisher Scientific Human IFN-gamma, Animal-Free Recombinant Protein, PeproTech

Applications

Functional Assay (Functional)

• Assay-dependent

In vitro Assay (IV)

• Refer to publications (72 available)

Miscellaneous PubMed (Misc)

• Refer to publications (5 available)

Product Specifications

Product Specific Information

Recombinant Human IFN-gamma is a 16.8 kDa protein containing 144 amino acid residues.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.

Target Information

IFN-gamma (Interferon gamma, Type II interferon) is a macrophage activation factor and immune interferon produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, and various cytokines.

• Dimeric protein consisting of two 146 amino acid subunits (~45 kDa functional homodimer).
• Appears as 25, 20, and minor 15.5 kDa bands on SDS-PAGE due to differential glycosylation.
• Highly species-specific; human IFN-gamma does not cross-react with mouse.
• Functions include antiviral activity, tumor antiproliferative effects, MHC induction, macrophage activation, and enhanced immunoglobulin secretion.
• Acts via IFN-gamma receptor I and II, activating the JAK-STAT pathway.
• Shares ~40% sequence homology with mouse IFN-gamma.
• Upregulated by IL-2, FGF basic, EGF; downregulated by vitamin D3 or DMN.
• Gene mutations associated with aplastic anemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.