Thermo Fisher Scientific Gtf2h5 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1.0 µg/mL
• Publications: 없음

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 100% | Dog: 100% | Guinea Pig: 100% | Human: 100% | Mouse: 100% | Rabbit: 100% | Rat: 100% | Zebrafish: 79%

Target Information

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.
In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment.
In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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