Thermo Fisher Scientific DAXX Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt.

Target Information

This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and cytoplasm. It interacts with various proteins such as apoptosis antigen Fas, centromere protein C, and transcription factor E26 oncogene homolog 1 (ETS family).
In the nucleus, DAXX functions as a potent transcription repressor binding to sumoylated transcription factors. Its repression can be relieved by sequestration into promyelocytic leukemia nuclear bodies or nucleoli.
The protein also associates with centromeres in G2 phase and may regulate apoptosis in the cytoplasm. Subcellular localization and function are modulated by post-translational modifications, including sumoylation, phosphorylation, and polyubiquitination.
Alternative splicing results in multiple transcript variants.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.