Thermo Fisher Scientific THRB Polyclonal Antibody
Zebrafish 반응성을 가진 Thermo Fisher Scientific의 THRB 폴리클로날 항체로, Western blot에 최적화됨. Goat IgG 기반으로 제작되었으며, 0.5 mg/mL 농도의 액상 형태. Thra와 교차반응하지 않으며 연구용으로만 사용 가능.
- 카탈로그번호
- PA5142283
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific THRB Polyclonal Antibody
Applications
- Western Blot (WB): 2–5 µg/mL
Publications
- [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Zebrafish |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-DIGSAPIVNAPEGNKVD |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2932935 |
Product Specific Information
- This antibody is not expected to cross-react to Thra.
- Tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
Thyroid hormone receptors (TR), also known as c-erbA-2, are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to hormone response elements following activation by the appropriate hormone.
Thyroid hormones regulate metabolic processes, growth, and development in many tissues by controlling expression of genes for growth hormone, malic enzyme, and several hepatic proteins.
There are two main forms of TR:
- TR alpha (chromosome 17)
- TR beta (chromosome 3)
Each form has two isoforms:
- TR alpha-1 and TR alpha-2
- TR beta-1 and TR beta-2
TR alpha-1 and TR alpha-2 are identical through amino acid 370 where their sequences diverge.
TR alpha-2, which does not bind T3, acts as a strong negative regulator of functional TR and is 80 amino acids longer than TR alpha-1.
The corresponding gene for thyroid hormone receptor beta-1 is NR1A2.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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