Thermo Fisher Scientific THRB Polyclonal Antibody

Applications

• Western Blot (WB): 2–5 µg/mL

Publications

• [References not provided]

Product Specifications

Product Specific Information

• This antibody is not expected to cross-react to Thra.
• Tested in Peptide ELISA: antibody detection limit dilution 1:32,000.

Target Information

Thyroid hormone receptors (TR), also known as c-erbA-2, are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to hormone response elements following activation by the appropriate hormone.
Thyroid hormones regulate metabolic processes, growth, and development in many tissues by controlling expression of genes for growth hormone, malic enzyme, and several hepatic proteins.

There are two main forms of TR:

• TR alpha (chromosome 17)
• TR beta (chromosome 3)

Each form has two isoforms:

• TR alpha-1 and TR alpha-2
• TR beta-1 and TR beta-2

TR alpha-1 and TR alpha-2 are identical through amino acid 370 where their sequences diverge.
TR alpha-2, which does not bind T3, acts as a strong negative regulator of functional TR and is 80 amino acids longer than TR alpha-1.
The corresponding gene for thyroid hormone receptor beta-1 is NR1A2.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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