Thermo Fisher Scientific Phospho-CXC Chemokine Receptor 4 (Ser324, Ser325) Polyclonal Antibody
CXCR4 단백질의 Ser324/Ser325 인산화 부위를 인식하는 Rabbit Polyclonal 항체. Western blot에 적합하며 인간과 생쥐 시료에 반응. 항원 친화 크로마토그래피로 정제된 액상 형태로, 연구용으로 HIV 관련 수용체 연구 및 신호전달 분석에 활용 가능.
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Thermo Fisher Scientific Phospho-CXC Chemokine Receptor 4 (Ser324, Ser325) Polyclonal Antibody
Applications
- Western Blot (WB): Tested dilution 1:1,000
- Publications: 1 publication available
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human CXCR4 around the phosphorylation site of Ser324/Ser325 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.4 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
CXCR4 (Fusin, LESTR, HUMSTR) is a G-protein-coupled chemokine receptor with seven transmembrane domains. It functions as a co-receptor for HIV-1 and HIV-2 entry into CD4+ cells, mediating viral fusion. CXCR4 also serves as a receptor for CXCL12/SDF-1, increasing intracellular calcium and activating MAPK1/MAPK3 signaling. Additionally, it plays roles in hematopoiesis, cardiac development, gastrointestinal vascularization, and CNS neuron survival. CXCR4 binds bacterial LPS and mediates inflammatory responses, including TNF secretion by monocytes. Antibodies to CXCR4 block HIV-1 and HIV-2 infection of human cells.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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