Thermo Fisher Scientific Myelin Protein Zero Polyclonal Antibody
Myelin Protein Zero를 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF, ELISA 등 다양한 응용에 적합합니다. Dog, Human, Mouse, Rat에 반응하며, Protein A로 정제된 1 mg/mL 액상 형태입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Myelin Protein Zero (amino acids 175–248) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Myelin Protein Zero (MPZ) is a Type I integral membrane glycoprotein that mediates adhesion of myelin sheath layers, ensuring stable synaptic transmission. It constitutes about 50% of the total protein in peripheral myelin, contributing to structural integrity. MPZ facilitates myelin wrapping through glycine zipper–dependent dimer and tetramer formation. Mutations such as G134R can disrupt multimerization, leading to demyelinating neuropathies including Charcot-Marie-Tooth disease. Its cytoplasmic domain undergoes serine and tyrosine phosphorylation during active nerve myelination. Expression is moderate in brain, abundant in thymus, and highest in CNS white matter.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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