Thermo Fisher Scientific MUPP1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human MUPP1. Recombinant protein control fragment (Product #RP-92907). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MUPP1,uniProtId:O75970-1,ncbiNodeId:9606,antigenRange:615-713,antigenLength:2070,antigenImageFileName:PA5-54168_MUPP1_O75970-1_Rabbit.svg,antigenImageFileNamePDP:PA5-54168_MUPP1_O75970-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2644306

Product Specific Information

Immunogen sequence: VVNILKELPI EVTMVCCRRT VPPTTQSELD SLDLCDIELT EKPHVDLGEF IGSSETEDPV LAMTDAGQST EEVQAPLAMW EAGIQHIELE KGSKGLGFS

Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 82%.

Target Information

MUPP1 (multi PDZ domain protein 1, MPDZ) was discovered as an interacting partner with the 5-HT2C receptor1, and was found to co-localize with 5-HT2A or 5-HT2C receptors in all regions of the mouse brain, including the choroid plexus. MUPP1 contains 13 PDZ domains but no apparent catalytic domain. MUPP1 is concentrated in tight junctions of polarized epithelial cells and binds to claudin-1 and junctional adhesion molecule (JAM). MUPP1 may therefore function as a multivalent scaffold protein that recruits various proteins to tight junctions. MUPP1 also interacts with claudin-8 and may play a role in tight junction barrier function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.