Thermo Fisher Scientific CACNG1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

Voltage-dependent calcium channels are essential for neurotransmitter release. L-type (long-lasting current) voltage-dependent calcium channels consist of four subunits: alpha1, beta, gamma, and alpha2-delta. The beta subunit is encoded by four genes (beta1–beta4), contributing to calcium current diversity and alpha1 subunit trafficking.
L-type Ca²⁺ channel gamma1 (also known as CACNLG or CACNG1) is a 222-amino-acid multi-pass membrane protein belonging to the PMP-22/EMP/MP20 family. Expressed in skeletal muscle, it functions as a subunit of the dihydropyridine (DHP)-sensitive calcium channel and may play a role in excitation–contraction coupling.
L-type Ca²⁺ channel gamma1 is also considered a marker for malignant hyperthermia susceptibility (MHS), an autosomal dominant skeletal muscle disorder that manifests as a life-threatening hypermetabolic crisis triggered by inhalation anesthetics and depolarizing muscle relaxants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.