Thermo Fisher Scientific CACNG1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human CACNG1. Validated for Western blot at 1:500–1:1,000 dilution. Supplied as liquid, 1 mg/mL concentration. Suitable for research use in studying L-type calcium channel gamma subunit function. Store at -20°C.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from the internal region of human CACNG1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2556088 |
Target Information
Voltage-dependent calcium channels are essential for neurotransmitter release. L-type (long-lasting current) voltage-dependent calcium channels consist of four subunits: alpha1, beta, gamma, and alpha2-delta. The beta subunit is encoded by four genes (beta1–beta4), contributing to calcium current diversity and alpha1 subunit trafficking.
L-type Ca²⁺ channel gamma1 (also known as CACNLG or CACNG1) is a 222-amino-acid multi-pass membrane protein belonging to the PMP-22/EMP/MP20 family. Expressed in skeletal muscle, it functions as a subunit of the dihydropyridine (DHP)-sensitive calcium channel and may play a role in excitation–contraction coupling.
L-type Ca²⁺ channel gamma1 is also considered a marker for malignant hyperthermia susceptibility (MHS), an autosomal dominant skeletal muscle disorder that manifests as a life-threatening hypermetabolic crisis triggered by inhalation anesthetics and depolarizing muscle relaxants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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