Thermo Fisher Scientific NEIL3 Polyclonal Antibody
NEIL3 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 최적화됨. Human 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. PBS/glycerol buffer에 보관되며, -20°C에서 장기 저장 가능. 연구용으로만 사용.
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Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from internal region of human NEIL3 (amino acids 312–334, UniProt ID: Q8TAT5-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635481 |
Product Specific Information
This antibody detects endogenous levels of total NEIL3 protein.
Target Information
NEIL3 is a DNA glycosylase that preferentially acts on single-stranded DNA (ssDNA) or partially single-stranded structures such as bubble and fork forms, rather than double-stranded DNA (dsDNA). It shows strong glycosylase activity toward hydantoin lesions including spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA, and also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg, and 8-oxoA lesions in ssDNA. No activity on 8-oxoG is detected. Additionally, it exhibits weak DNA-(apurinic/apyrimidinic site) lyase activity. In vivo, NEIL3 is the primary enzyme responsible for removing Sp and Gh from ssDNA in neonatal tissues and plays a role in replication-associated DNA repair, supporting cell proliferation in neural progenitor and tumor cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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