Thermo Fisher Scientific PRDM16 Polyclonal Antibody
PRDM16 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB 및 IHC에 사용 가능. 인간, 생쥐, 랫트에 반응하며 항원 친화 크로마토그래피로 정제됨. PRDM16 관련 세포 분화 및 암 연구에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptides corresponding to human PRDM16/MEL1 (236–251, 23–40) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 30% glycerol, 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2664823 |
Product Specific Information
This antibody is predicted to react with Monkey, Mouse, Dog.
Target Information
PRDM16 is a zinc finger transcription factor containing an N-terminal PR domain. The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and is specifically expressed in t(1;3)(p36,q21)-positive MDS/AML. The translocation results in overexpression of a truncated protein lacking the PR domain, potentially contributing to MDS and AML pathogenesis.
PRDM16 acts as a Smad3 binding protein, important in orofacial development via TGF-beta signaling modulation, and controls cell fate between skeletal myoblasts and brown fat cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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