Thermo Fisher Scientific IRAK1 Polyclonal Antibody
IRAK1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. Western blot 및 immunoprecipitation에 사용 가능. 인간, 마우스, 랫트 반응성. Protein G로 정제된 0.5 mg/mL 액상 형태로 제공. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
Immunoprecipitation (IP)
- Tested Dilution: 2–4 µg/sample
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 700–712 of human IRAK |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2126160 |
Product Specific Information
- Suggested positive control: HeLa or NIH-3T3 whole cell lysate.
Target Information
IL-1 receptor-associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. IRAK1 is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Its association with MYD88 leads to phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. IRAK1 can also phosphorylate TIRAP to promote its ubiquitination and degradation, and phosphorylate IRF7 to induce activation and nuclear translocation, leading to transcriptional activation of type I IFN genes and antiviral responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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