Thermo Fisher Scientific ITM2B Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
YFALQPDDVY YCGIKYIKDD VILNEPSADA PAALYQTIEE NIKIFEEEEV EFISVPVPEF ADSDPANIVH DFNKKLTAYL DLNLDKCYVI PLNTSIVMPP RNLLELLINI KAGTYLPQSY LIHEHMVITD RIENIDHLGF FIYRLCH

Target Information

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease.
This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide that inhibits the deposition of beta-amyloid.
Mutations extending the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurodegenerative diseases — familial British dementia and familial Danish dementia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.