Thermo Fisher Scientific HPK1 Polyclonal Antibody
Human MAP4K1(HPK1)을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제되었으며, PBS 기반 완충액에 보존. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MAP4K1 (amino acids 288–407, UniProt ID: Q92918-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2789458 |
Product Specific Information
Immunogen sequence:
LDKLKNPGKG PSIGDIEDEE PELPPAIPRR IRSTHRSSSL GIPDADCCRR HMEFRKLRGM ETRPPANTAR LQPPRDLRSS SPRKQLSESS DDDYDDVDIP TPAEDTPPPL PPKPKFRSPS
Target Information
MAP4K1 (also known as HPK1, Hematopoietic progenitor kinase 1) is a hematopoietic cell-restricted member of the Ste20 serine/threonine kinase superfamily. It acts as a tissue-specific upstream activator of the MEKK/JNK/SAPK signaling pathway.
MAP4K1 negatively regulates T cell receptor (TCR) signaling and T cell proliferation by phosphorylating the adaptor protein SLP-76. The JNK/SAPK pathway is crucial for cellular stress responses and blood cell differentiation.
HPK1 is related to the p21(Cdc42/Rac1)-activated kinase (PAK) and yeast STE20, both involved in MAPK cascades. Expression of HPK1 specifically activates JNK1 and enhances AP-1-mediated transcription. HPK1 binds and phosphorylates MEKK1 directly, but unlike PAK65, it lacks the Rac1/Cdc42-binding domain, indicating a distinct regulatory mechanism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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