Thermo Fisher Scientific CD47/IAP (Integrin Associated Protein) Recombinant Rabbit Monoclonal Antibody (CD47, 6364R)
CD47/IAP 단백질을 표적으로 하는 Thermo Fisher Scientific의 재조합 토끼 단일클론 항체입니다. 사람 시료에 반응하며, IHC(P) 실험에 최적화되어 있습니다. 고순도 Protein A/G 정제, 액상 형태로 제공되며 4°C 보관이 권장됩니다.
- 카탈로그번호
- 961-RBM14-P1
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | CD47, 6364R |
| Immunogen | Recombinant fragment (aa 18–135) of human CD47 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
- For formalin-fixed tissues, heat sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, then cool at room temperature for 20 min.
Target Information
CD47 (integrin-associated protein, IAP) is a cell surface transmembrane glycoprotein that interacts with integrins and regulates their functions. Engagement of CD47 modulates signaling pathways such as activation of heterotrimeric G proteins and intracellular calcium increase upon cell adhesion.
It also serves as a receptor for thrombospondin’s C-terminal domain and plays roles in membrane transport and signal transduction.
CD47 is broadly distributed across tissues, reduced on Rh erythrocytes, and acts as a ligand for CD172a (SIRPα), preventing macrophage-mediated phagocytosis of CD47-positive cells.
Additionally, the CD47–CD172a system influences cell migration, B cell adhesion, T cell activation, chondrocyte mechanotransduction, and neuronal development, being abundant in synapse-rich regions of brain and retina.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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