Thermo Fisher Scientific Human TYW1 Synthetic Peptide

Thermo Fisher Scientific Human TYW1 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 19 amino acids near the carboxy terminus of human TYW1.
PEP-1266 can be used as a blocking peptide with polyclonal antibody PA5-21152.

Target Information

TYW1 (also known as TYW1A, RSAFD1, YPL207W) is a 732 amino acid protein containing one flavodoxin-like domain that participates in the wybutosine-tRNA (Phe) biosynthesis pathway.
Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome.
TYW1 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during ribosomal decoding, ensuring correct translation.
TYW1 binds to one 4Fe-4S cluster and is located on human chromosome 7.
Defects in some genes on chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Lissencephaly, Citrullinemia, and Shwachman-Diamond syndrome, suggesting TYW1 may play a role in these conditions.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.