Thermo Fisher Scientific Phospho-TRIM25 (Ser100) Polyclonal Antibody
Phospho-TRIM25 (Ser100) 특이적 Rabbit Polyclonal Antibody로 인간, 생쥐, 랫트 반응성. WB, IHC, ICC, ELISA 등 다양한 응용에 적합. Protein A 정제, 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human TRIM25 around the phosphorylation site of Ser100 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TRIM25, also known as estrogen responsive finger protein (EFP), is a member of the RING finger-B box-coiled coil family and a downstream target of estrogen receptor α. Mice lacking this gene display underdeveloped uterus and reduced estrogen responsiveness, indicating its essential role in estrogen-dependent proliferation. TRIM25 expression increases in breast carcinoma, promoting tumor growth by acting as an E3 ubiquitin ligase targeting the negative cell cycle checkpoint 14-3-3σ. Recent studies show TRIM25 E3 ubiquitin ligase is crucial for the RIG-I signaling pathway to elicit host antiviral innate immunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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