Thermo Fisher Scientific Phospho-Tau (Ser404) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules.
The C-terminus binds axonal microtubules, while the N-terminus binds neural plasma membrane components, functioning as a linker between both.
Axonal polarity is determined by Tau/MAPT localization within the neuronal cell body domain defined by the centrosome.

Short isoforms of Tau allow cytoskeletal plasticity, while longer isoforms contribute to stabilization. In its hyper-phosphorylated form, Tau forms paired helical filaments (PHF), a major component of neurofibrillary lesions in Alzheimer’s disease (AD) brains.
Hyper-phosphorylation impairs Tau’s microtubule-binding ability, destabilizing microtubules and leading to neuronal degeneration.

Numerous serine/threonine kinases phosphorylate Tau, including:

• GSK-3β
• Protein kinase A (PKA)
• Cyclin-dependent kinase 5 (cdk5)
• Casein kinase II

Hyper-phosphorylated Tau is found in neurofibrillary lesions in various CNS disorders such as Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.