Thermo Fisher Scientific RICH2 Polyclonal Antibody
RICH2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 적용 가능. 인간 단백질에 반응하며, 항원 친화 크로마토그래피로 정제됨. 액상 형태로 제공되며 장기 보관 시 -20°C에서 보관 권장.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human RICH2. Recombinant protein control fragment (Product #RP-102315). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2646558 |
Product Specific Information
Immunogen sequence:
STPSPYGLSY PQGYSLASGQ LSPAAAPPLA SPSVFTSTLS KSRPTPKPRQ RPTLPPPQPP TVNLSASSPQ STEAPMLDGM SPGESMSTDL VHFDIPSIHI ELGSTLRLSP LEHMRRHSVT DKRDSE
Highest antigen sequence identity to the following orthologs:
- Mouse: 92%
- Rat: 93%
Target Information
GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Controls cycling between active GTP-bound and inactive GDP-bound states. Acts as a GAP for CDC42 and RAC1. In neurons, involved in dendritic spine formation and synaptic plasticity through RAC1-GAP activity. Limits initiation of exploratory dendritic filopodia and binds to plasma membrane sections deformed inward by acto-myosin contractile forces. Through GAP activity on RAC1, reduces actin polymerization necessary for filopodia formation. In association with SHANK3, promotes GRIA1 exocytosis and spine morphological changes associated with long-term potentiation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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