Thermo Fisher Scientific TLR8 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 849-1041 of human TLR8 (NP_6195421) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TLR8,uniProtId:Q9NR97-1,ncbiNodeId:9606,antigenRange:849-1041,antigenLength:1041,antigenImageFileName:PA5-90109_TLR8_Q9NR97-1_Rabbit.svg,antigenImageFileNamePDP:PA5-90109_TLR8_Q9NR97-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.16 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2805926

Product Specific Information

Positive Samples: Mouse liver; Cellular Location: Membrane, Single-pass type I membrane protein

Immunogen sequence: HHLFYWDVWF IYNVCLAKVK GYRSLSTSQT FYDAYISYDT KDASVTDWVI NELRYHLEES RDKNVLLCLE ERDWDPGLAI IDNLMQSINQ SKKTVFVLTK KYAKSWNFKT AFYLALQRLM DENMDVIIFI LLEPVLQHSQ YLRLRQRICK SSILQWPDNP KAEGLFWQTL RNVVLTENDS RYNNMYVDSI KQY

Target Information

The TLR8 protein is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. The TLR8 gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.