Thermo Fisher Scientific TRPV6 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total TRPV6.

Target Information

Calcium-permeable channels such as TRPV6 participate in neurotransmission, muscle contraction, and exocytosis by providing calcium as an intracellular second messenger. Depending on the tissue, transcellular calcium transport may be regulated by vitamin D, parathyroid hormone (PTH), or calcitonin (CALCA).
TRPV6 functions as a calcium-selective cation channel involved in Ca²⁺ uptake in various tissues, including intestinal Ca²⁺ reabsorption. The channel is activated by low internal calcium levels and exhibits inward rectification.
Inactivation involves both rapid Ca²⁺-dependent and slower Ca²⁺-calmodulin-dependent mechanisms, the latter possibly regulated by phosphorylation. In vitro, it is slowly inhibited by Mg²⁺ in a voltage-independent manner.
Heteromeric assembly with TRPV5 modifies channel properties, and TRPV5–TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. TRPV6 interacts with TRPV5, S100A10, ANAX2–S100A10 heterotetramer, BSPRY, and calmodulin. Interaction with S100A10 is required for trafficking to the plasma membrane.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.