Thermo Fisher Scientific UFD1L Polyclonal Antibody
Thermo Fisher Scientific의 UFD1L Polyclonal Antibody는 인간, 생쥐, 랫트에서 반응하며 Western blot, IHC, ICC/IF에 사용 가능합니다. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공되며 -20°C에서 보관합니다. 연구용으로 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human UFD1 (Accession Q92890), corresponding to amino acid residues G218–I268 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2815719 |
Product Specific Information
Antibody detects endogenous levels of total UFD1L.
Target Information
Ubiquitin-mediated proteolysis involves the transfer of ubiquitin (Ub) to lysine residues on target proteins, promoting their degradation by the 26S proteasome. Ub-fusions are processed by Ub-specific proteases (UBps) or through the Ub-fusion degradation (UFD) pathway.
The UFD1 protein, first identified in yeast S. cerevisiae, has a human homolog known as UFD1L. In vitro, UFD1 attenuates degradation of Ub-fusions with specific amino acid substitutions at Gly76, influencing multiubiquitination processes.
Mutations in the UFD1 gene are associated with CATCH22 syndrome, characterized by cardiac defects, cleft palate, and hypocalcemia, suggesting a role for UFD1 in developmental processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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