Thermo Fisher Scientific IL-1 Alpha Polyclonal Antibody
IL-1 Alpha 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC, ELISA 등 다양한 응용에 적합. Human 시료 반응성. Protein A로 정제된 고순도 제품으로 안정적 액상 형태 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human IL-1 Alpha, amino acids 151–220 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
IL-1 alpha (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is encoded by the IL1A gene located on chromosome 2q13 and signals through IL-1RI and IL-1RII receptors, shared with IL-1 beta.
IL-1 alpha plays a key role in innate host defense by inducing other proinflammatory cytokines and acute-phase responses. Its activity is moderated by IL-1 Receptor Antagonist (IL-1RA), which competitively inhibits receptor binding.
This cytokine is involved in immune regulation, inflammation, and hematopoiesis, and is produced as a proprotein processed upon cell injury to induce apoptosis. IL1A, along with other interleukin-1 family genes, forms a cytokine gene cluster on chromosome 2.
IL-1 alpha regulates NF-kappaB and MAPK pathways, stimulates IL-6 and COX-2 expression, and increases nitric oxide production. Elevated IL-1 alpha levels are associated with chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, and multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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