Thermo Fisher Scientific ACAP2 Polyclonal Antibody
ACAP2 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunoprecipitation에 적합하며, 인간, 쥐, 토끼에서 반응 가능. 4°C 보관, 액상 형태, 비결합(Unconjugated) 항체.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 728 to 778 of human ArfGAP with Coiled-coil, Ankyrin Repeat and PHD domains 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Rat and Rabbit
Target Information
ACAP2 is a transport carrier belonging to the Centaurin family with three ANK repeats, an Arf-GAP domain, a BAR domain, and a PH domain.
ACAP2 acts as a GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) with robust constitutive ARF6 GAP activity. This activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid, but shows little activity toward ARF1.
ACAP2 controls the return of ARF to the inactive GDP-bound state. Along with ACAP1, it is targeted by phosphatidylinositol (3,4,3) triphosphate, inhibiting PDGF-induced dorsal membrane ruffle formation in NIH3T3 fibroblasts when overexpressed.
ACAP2 is phosphorylated upon DNA damage, likely by ATM or ATR, and shows widespread expression with highest levels in lung tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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