Thermo Fisher Scientific COMT Polyclonal Antibody
Human COMT 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western Blot에 적합. 항원 친화 크로마토그래피로 정제됨. PBS/glycerol buffer에 보관하며 장기 저장 시 -20°C 권장. 도파민, 에피네프린, 노르에피네프린 대사 연구용.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human COMT. Recombinant protein control fragment (Product #RP-91340) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640045 |
Product Specific Information
Immunogen sequence:
YCEQKEWAMN VGDKKGKIVD AVIQEHQPSV LLELGAYCGY SAVRMARLLS PGARLITIEI NPDCAAITQR MVDFAGVKDK VTLVVGASQD IIPQLKKKYD VDTLDMVFLD HWKDRYLPDT LLLEECGLLR KGTVLLADNV ICPGAPDFLA HVRGSSCFEC THYQSFLEYR EVVDGLEKAI Y
- Highest antigen sequence identity to the following orthologs:
- Mouse: 82%
- Rat: 82%
Target Information
Catechol-O-methyltransferase (COMT) catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including dopamine, epinephrine, and norepinephrine.
This O-methylation is a major degradative pathway of catecholamine transmitters. COMT also metabolizes catechol drugs used to treat hypertension, asthma, and Parkinson’s disease.
COMT exists in two forms in tissues: soluble (S-COMT) and membrane-bound (MB-COMT), differing in their N-termini. Multiple transcript variants arise from alternative translation initiation sites and promoters.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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