Thermo Fisher Scientific Mouse SCF Recombinant Protein
Mouse SCF 재조합 단백질로, E. coli에서 발현된 순도 ≥95%의 단백질입니다. 인간 TF-1 세포 증식으로 활성 검증된 고품질 연구용 시약이며, 세포 성장 및 신호전달 연구에 적합합니다. 냉동(-20°C) 보관 및 동결-해동 반복을 피해야 합니다.
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Thermo Fisher Scientific Mouse SCF Recombinant Protein
Applications
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Mouse |
| Expression System | E. coli |
| Amino Acid Sequence | MKEICGNPVT DNVKDITKLV ANLPNDYMIT LNYVAGMDVL PSHCWLRDMV IQLSLSLTTL LDKFSNISEG LSNYSIIDKL GKIVDDLVLC MEENAPKNIK ESPKRPETRS FTPEEFFSIF NRSIDAFKDF MVASDTSDCV LSSTLGPEKD SRVSVTKPFM LPPVA |
| Molecular Weight | 18.4 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥95% |
| Endotoxin Concentration | ≤0.1 EU/µg |
| Activity | ED50 ≤20 ng/mL (human TF-1 cell proliferation assay) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.1 mg/mL |
| Purification | Purified |
| Storage Buffer | 20 mM sodium phosphate, pH 6.5 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Product Specific Information
Reconstitute in sterile water to 0.1 mg/mL. Centrifuge vial before opening. Suspend the product by gently pipetting the recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution.
For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze-thaw cycles.
Target Information
Stem Cell Factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways.
Binding of SCF to the c-Kit receptor induces receptor homodimerization and activates signaling pathways such as PI-3, PLC-γ, Jak/STAT, and MAP kinase.
SCF promotes mast cell survival and the release of histamine, pro-inflammatory cytokines, and chemokines.
Inhibition of the SCF/c-Kit pathway reduces histamine levels, mast cell and eosinophil infiltration, IL-4 production, and airway hyperresponsiveness, suggesting this pathway as a potential therapeutic target for inflammatory diseases such as asthma.
At least two isoforms of SCF are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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