Thermo Fisher Scientific Human IRGM Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 17 amino acids near the amino terminus of human IRGM.
PEP-0627 can be used as a blocking peptide with polyclonal antibody PA5-20507.

Target Information

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway, is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components.

Two of the strongest hits implicate genes IRGM and ATG16L1, which encode proteins critical to the autophagy pathway and are significantly associated with Crohn's disease.

In mouse, IRGM belongs to a family of gamma-interferon-induced GTP-binding proteins of approximately 48 kDa. Murine IRGM induces autophagy and generates large autolysosomal organelles as a mechanism for eliminating intracellular Mycobacterium tuberculosis. Human IRGM is also involved in autophagy and plays a role in controlling intracellular pathogens and reducing intracellular bacillary load.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.