Thermo Fisher Scientific ATF6 Polyclonal Antibody
ATF6 단백질을 표적하는 Thermo Fisher Scientific의 다클론 항체로, 인간·마우스·랫트 반응성을 보입니다. WB, IHC, ICC, ELISA 등 다양한 응용에 적합하며, 고순도 Protein A 정제 및 안정적인 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human ATF6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ATF6 is a transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. It binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires NF-Y binding.
ATF6 can form homodimers and heterodimers with ATF6 beta, interacting with NF-Y through the NF-YC subunit. It also interacts with transcription factors GTF2I, YY1, and SRF. Under ER stress, the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
The basic domain acts as a nuclear localization signal, while the leucine-zipper domain mediates NF-Y binding. During unfolded protein response, a ~50 kDa cytoplasmic fragment is released by proteolysis via site-1 and site-2 proteases.
ATF6 is N-glycosylated, phosphorylated in vitro by MAPK14/P38MAPK, and belongs to the bZIP family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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