Thermo Fisher Scientific CPA6 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

Members of the M14 metallocarboxypeptidase protein family serve many diverse functions and are divided into three subfamilies based on structure, function, and amino acid sequence similarity. As a member of the A/B subfamily, CPA6 (Carboxypeptidase A6) is a 437 amino acid secreted, zinc-binding protein that contains a characteristic propetide at the amino terminus, which is cleaved off upon enzyme activation.

Although expressed broadly in embryonic tissues, CPA6 is found at highest levels in the adult olfactory bulb and epididymis. CPA6 functions to cleave large C-terminal hydrophobic residues from protein substrates and is likely involved in extracellular processing of neuropeptides. Mutations in the CPA6 gene have been linked to Duane syndrome, a congenital eye-movement disorder characterized by abnormal development of cranial nerve VI (the abducens nerve). Three isoforms of CPA6 exist as a result of alternative splicing events.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.