Thermo Fisher Scientific BAP1 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Predicted to react with Mouse, Rat, Zebrafish, X. tropicalis, Chicken, and Bovine (based on 100% sequence identity)

Target Information

BRCA1-associated protein-1 (BAP1) interacts with the RING finger domain of BRCA1. The N-terminal 240 amino acids of the 729-amino acid human protein show homology to ubiquitin C-terminal hydrolases (UCHs), which are thiol proteases catalyzing proteolytic processing of ubiquitin.
BAP1 contains an acidic region, a highly charged C-terminal region, and two putative nuclear localization signals. It associates with BRCA1 in vivo and exhibits overlapping subnuclear localization patterns. BAP1 enhances BRCA1-mediated inhibition of breast cancer cell growth.

Northern blot analysis indicates that BAP1 is expressed as a 4-kb mRNA in all human tissues tested, with a 4.8-kb transcript expressed exclusively in testis.
BAP1 and BRCA1 are coexpressed during murine breast development and remodeling. The BAP1 gene maps to 3p21.3, a region frequently deleted in breast and lung carcinomas. Intragenic homozygous rearrangements and deletions of BAP1 appear in lung carcinoma cell lines, suggesting BAP1 functions as a tumor suppressor gene in the BRCA1 growth control pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.