Thermo Fisher Scientific Phospho-Androgen Receptor (Tyr363) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. It has three major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The receptor binds active testosterone (T) and dihydrotestosterone (DHT), functioning as a ligand-activated transcription factor. Upon ligand binding, AR translocates to the nucleus, dimerizes, and activates transcription of androgen-responsive genes.

AR signaling plays a key role in the development and function of male reproductive organs such as the prostate and epididymis, and also in nonreproductive tissues like muscle, hair follicles, and brain. AR is a phosphoprotein that interacts with the MAP kinase pathway, and changes in its phosphorylation state correlate with MEK1/2 pathway activity. Dysregulation of AR signaling is associated with diseases such as prostate cancer, Kennedy’s disease, and male infertility. Mutations in the AR gene can cause complete androgen insensitivity (CAIS).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.