Thermo Fisher Scientific Phospho-Androgen Receptor (Tyr363) Polyclonal Antibody
인산화된 Androgen Receptor (Tyr363)을 인식하는 토끼 다클론 항체로, Western blot, IHC, ICC 등 다양한 응용에 적합합니다. 인간, 마우스, 랫트에 반응하며, Protein A로 정제된 고순도 항체입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human Androgen Receptor around the phosphorylation site of Tyr363 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. It has three major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The receptor binds active testosterone (T) and dihydrotestosterone (DHT), functioning as a ligand-activated transcription factor. Upon ligand binding, AR translocates to the nucleus, dimerizes, and activates transcription of androgen-responsive genes.
AR signaling plays a key role in the development and function of male reproductive organs such as the prostate and epididymis, and also in nonreproductive tissues like muscle, hair follicles, and brain. AR is a phosphoprotein that interacts with the MAP kinase pathway, and changes in its phosphorylation state correlate with MEK1/2 pathway activity. Dysregulation of AR signaling is associated with diseases such as prostate cancer, Kennedy’s disease, and male infertility. Mutations in the AR gene can cause complete androgen insensitivity (CAIS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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