Thermo Fisher Scientific URP1 Polyclonal Antibody
Rabbit polyclonal antibody against human URP1 protein residues 643-660. Validated for Western blot (1:1,000 dilution). Unconjugated, liquid form at 1 mg/mL concentration. High sequence conservation across multiple species. For research use only...
- 카탈로그번호
- RA19033-100UG
- 판매단위
- pk
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Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Residues 643–660 (VHEYIGGYIFLSTRSKDQ) of the 77 kDa human URP1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
Sequence is 100% conserved between almost all species (mouse, rat, canine, bovine, chimpanzee, Xenopus).
Target Information
Kindlin 1 is a member of the kindlin family of focal adhesion proteins and contains a FERM domain and pleckstrin homology domain.
It is involved in integrin signaling, linkage of the cytoskeleton to the extracellular matrix, and cell adhesion.
Most often expressed in epithelial cells, Kindlin 1 coexpressed with talin helps activate ITGA2B.
It is required for keratinocyte proliferation, polarization of basal keratinocytes, and maintenance of normal cell shape.
Mutations in Kindlin 1 are associated with Kindler syndrome, a recessive skin disorder characterized by blistering, photosensitivity, poikiloderma, and atrophy.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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