Thermo Fisher Scientific IL1F6 Monoclonal Antibody (OTI1D11), TrueMAB
IL1F6 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot, ICC/IF, Flow cytometry에 적합. 인간 시료에 반응하며, 고순도 친화 크로마토그래피로 정제됨. 연구용으로 NF-κB 및 MAPK 경로 관련 염증 반응 연구에 활용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1D11 |
| Immunogen | Full length human recombinant protein of human IL1F6 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.45 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The IL-1 family comprises 11 structurally related ligands, including IL-36α (IL-1F6), β (IL-1F8), and γ (IL-1F9).
IL-36α is highly expressed in psoriatic plaques and is uniquely expressed by T cells, monocytes, and B cells.
It is found primarily in skin and lymphoid tissues, with lower expression in fetal brain, trachea, stomach, and intestine.
IL-36α signals through IL-1Rrp2 (IL-1R6) and IL-RAcP receptors, activating NF-κB and MAPK pathways, and induces proinflammatory cytokines and chemokines such as IL-6, IL-8, BD-2, and BD-3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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