Thermo Fisher Scientific WTAP Polyclonal Antibody
Human WTAP 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC 및 IHC(Paraffin) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 4°C에서 보관합니다. 연구용으로만 사용됩니다.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:50–1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 346 and 396 of Human Wilms tumor 1 associated protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with X. laevis, X. tropicalis, Bovine, Horse, Guinea pig, Pig, Panda, Orangutan, Monkey, Gorilla, and Chimpanzee.
Target Information
Wilms’ tumor (WT) is an embryonal malignancy of the kidney that affects approximately 1 in 10,000 infants and occurs in both sporadic and inherited forms.
WT1 binds the DNA sequence GCGGGGGCG and functions as a transcriptional repressor.
WTAP (Wilms tumor 1-associating protein) is a ubiquitously expressed nuclear protein that interacts with WT1 and may regulate mRNA splicing.
WTAP localizes to nuclear speckles and regulates the G2/M cell cycle transition by binding to the 3′ UTR of cyclin A2, enhancing its stability.
Additionally, WTAP inhibits WT1 target gene expression and impairs WT1 DNA binding ability.
Two isoforms of WTAP exist due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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