Thermo Fisher Scientific Sorcin Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended positive controls: HeLa, 293T, A431, H1299, HeLaS3, Molt-4, Raji, mouse heart
• Predicted reactivity: Mouse (97%), Rat (94%), Xenopus laevis (80%), Pig (99%), Chicken (86%), Sheep (99%), Rhesus Monkey (99%), Bovine (99%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Sorcin is a 198 amino acid, soluble, resistance-related, calcium-binding cytosolic protein belonging to the penta-EF hand (PEF) family of calcium-binding proteins and contains four EF-hand calcium-binding motifs.
Human Sorcin shares 95% sequence identity with hamster Sorcin. It associates with sarcolemmal proteins such as Annexin VII, cardiac ryanodine receptors, and L-type Ca²⁺ channels, influencing intracellular calcium homeostasis.
It plays a critical role in regulating intracellular Ca²⁺ cycling and influx pathways in heart and skeletal muscle during excitation-contraction.
Overexpression of Sorcin is observed in many multidrug-resistant (MDR) cells, where it regulates apoptosis pathways, serving as a potential MDR marker for prognosis of acute myeloid leukemia (AML) and a target for anti-MDR drug development.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.