Thermo Fisher Scientific CHRNA1 Polyclonal Antibody

Thermo Fisher Scientific CHRNA1 Polyclonal Antibody

Product Specifications

Product Specific Information

Immunogen sequence:
MKLGTWTYDG SVVAINPESD QPDLSNFMES GEWVIKESRG WKHSVTYSCC PDTPYLDITY HF

Target Information

Acetylcholine receptors (AChRs) mediate synaptic transmission at the neuromuscular junction. The channel-linked AChR that mediates rapid, excitatory actions of acetylcholine is called nicotinic AChR (nAChR) because it can be activated by nicotine.
The non-channel linked AChR that mediates the slow actions of acetylcholine, which can be either inhibitory or excitatory, is called muscarinic AChR (mAChR) because it can be activated by muscarine.

The nAChRs fall into two subclasses, the muscle-type and the neuronal-type. The muscle-type receptor is a pentameric glycoprotein of five membrane-spanning subunits (2 alpha 1’s, beta 1, gamma or epsilon, and delta), which form a ligand-gated ion channel.
The neuronal nAChR is also a pentamer, but unlike the muscle-type, is made up of only two general types of subunits, alpha and beta, of which multiple subtypes have been described (alpha 2 to alpha 8 and beta 2 to beta 4).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.