Thermo Fisher Scientific SATB1 Polyclonal Antibody
Human, Mouse, Rat에 반응하는 Rabbit Polyclonal SATB1 항체로, WB, IHC, ICC/IF, ChIP 등 다양한 응용에 적합. 1 mg/mL 농도의 액상 제품이며, 항원 친화 크로마토그래피로 정제됨. 연구용으로만 사용 가능.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific SATB1 Polyclonal Antibody
Thermo Fisher Scientific SATB1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 20 µg/mL |
| ChIP assay (ChIP) | 2.5 µg/10^6 cells |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid peptide near the amino terminus of the human SATB1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months; for long-term storage store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152459 |
Product Specific Information
- Suggested positive control: SK-N-SH cell lysate
- PA5-20535 can be used with blocking peptide PEP-0655
Target Information
SATB1 (DNA-binding protein SATB1) is a crucial silencing factor involved in X inactivation mediated by Xist RNA during embryogenesis and lymphoma. It binds to AT-rich DNA sequences and nuclear matrix/scaffold-associated regions, recognizing the sugar-phosphate structure of double-stranded DNA. SATB1 acts as a transcriptional repressor, controlling nuclear and viral gene expression in a phosphorylation- and acetylation-dependent manner. It modulates genes essential for T-cell maturation and influences chromatin context targeted by HIV-1 integration machinery. HIV-1 Tat may overcome SATB1-mediated repression by binding to the same domain as HDAC1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.