Thermo Fisher Scientific USP8 Polyclonal Antibody
USP8 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western Blot, IHC, IP 등 다양한 응용 가능. 액상 형태로 제공되며, 4°C에서 보관. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:200–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 400 and 450 of Human Ubiquitin Specific Peptidase 8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
USP8 is a ubiquitin specific protease that plays an important regulatory role in protein turnover by preventing degradation. It is involved in cell proliferation and likely regulates the stability of STAM2 and RASGRF1. USP8 may regulate T-cell energy mediated by RNF128 via forming a complex containing RNF128 and STAM2. Structure/function studies reveal that USP8 forms a ternary complex with RNF128 and OTUB1, interacting with the SH3 domain of STAM2 and RASGRF1. Expression of USP8 increases upon growth stimulation in starved human fibroblasts and decreases in response to growth arrest induced by cell-cell contact.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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